While short-term use may only produce little, short-term results in the brain, prolonged substance usage changes the brain in basic ways that strengthen continued use, such as the conditioning of memory circuits associated with drug taking. Cues that are social (such as being around substance-using good friends), geographical (previous favorite bars), and physical (experiencing tension) in nature become strongly connected with the drug.Brain changes from persistent drug or alcohol usage can persist years after an individual quits. This is why individuals risk regression even after long periods of abstaining, and regardless of a regression's possibly terrible results. More importantly, this is why treatment depends on the kind of drug and the private qualities of the patient.