While short-term use may just produce little, short-term results in the brain, prolonged substance use changes the brain in essential manner ins which reinforce continued usage, such as the fortifying of memory circuits related to drug taking. Cues that are social (such as being around substance-using good friends), geographical (previous favorite bars), and physical (experiencing stress) in nature end up being highly related to the drug.Brain changes from persistent drug or alcohol usage can continue years after an individual quits. This is why people risk regression even after long durations of abstaining, and despite a relapse's possibly destructive effects. More significantly, this is why treatment depends on the type of drug and the specific characteristics of the client.